abstract：:The efficacy and safety of Naprelan (naproxen sodium) 1000 mg once daily (QD) and nabumetone 1500 mg QD were compared in a multicenter, randomized, parallel-group, placebo-controlled, double-masked, 4-week study of adult outpatients with active osteoarthritis (OA) of the knee. Nabumetone 1500 mg was chosen for compari...

journal_title：Clinical therapeutics

authors： Fleischmann RM,Flint K,Constantine G,Kolecki B

更新日期：1997-07-01 00:00:00

abstract：:To optimize the efficacy of radiotherapy for cancer patients who are pregnant, the following factors must be considered: the potential effects of the therapy on fetuses and neonates, the stage and prognosis of the mother's disease, and the possible risks to the patient of restricting cancer treatment. Malformations an...

journal_title：Clinical therapeutics

authors： Nakagawa K,Aoki Y,Kusama T,Ban N,Nakagawa S,Sasaki Y

更新日期：1997-07-01 00:00:00

abstract：:The effects of 4 weeks of treatment with doxazosin or enalapril on diastolic blood pressure (DBP) and plasma lipid levels were studied in 160 patients 18 to 50 years old with mild-to-moderate hypertension. Comparing baseline measurements with measurements taken after 4 weeks, DBP was significantly reduced by 6.8 +/- 7...

journal_title：Clinical therapeutics

authors： Tan KW,Frise SA

更新日期：1997-05-01 00:00:00

abstract：:The objective of this study was to compare the cost of intravenous adenosine and intravenous dipyridamole in positron emission tomography (PET) in patients with coronary artery disease. A retrospective, open-label, case-control, cost-effectiveness analysis was performed in the out-patient nuclear medicine department o...

journal_title：Clinical therapeutics

authors： Holmberg MJ,Mohiuddin SM,Hilleman DE,Lucas BD Jr,Wadibia EC

更新日期：1997-05-01 00:00:00

abstract：:Zuclopenthixol acetate is a rapid-acting, injectable neuroleptic drug with a duration of action that allows for administration once every 2 to 3 days, in contrast to injectable haloperidol, which may require administration more than once daily. To assess the place of zuclopenthixol acetate in the treatment of acute ep...

journal_title：Clinical therapeutics

authors： Laurier C,Kennedy W,Lachaine J,Gariepy L,Tessier G

更新日期：1997-03-01 00:00:00

abstract：:In this double-masked, double-dummy, randomized, single crossover study, we compared single doses of a fast-dissolving wafer formulation of famotidine with a conventional tablet formulation of ranitidine in patients with gastroesophageal reflux disease (GERD). Patient preference time until symptomatic relief, and pred...

journal_title：Clinical therapeutics

authors： Johannessen T,Kristensen P

更新日期：1997-01-01 00:00:00

abstract：:The comparative bioavailability of ceftibuten, a new third-generation cephalosporin antibiotic given orally once daily, in capsule and suspension dosage forms, was assessed in healthy male subjects. In three separate studies, subjects received either a 400-mg dose as a suspension or one laboratory-batch, 400-mg capsul...

journal_title：Clinical therapeutics

authors： Lin CC,Affrime M,Radwanski E,Lim J,Colucci R,Cayen MN

更新日期：1996-11-01 00:00:00

abstract：:The overall objective of this research project was to measure the types and amounts of Mexican drug products being purchased and declared to US Customs by US residents crossing the border in Laredo, Texas. Data for this study were obtained from the US Customs Declaration Form, which each person completes as he or she ...

journal_title：Clinical therapeutics

authors： McKeithan EK,Shepherd MD

更新日期：1996-11-01 00:00:00

abstract：:After a brief analysis of the financial and health care motives that have led to the current boom in disease management (DM) programs, this paper discusses the pragmatic realities of a particular DM program for treating asthma. A model of the institutional structures necessary for DM to work is presented, emphasizing ...

journal_title：Clinical therapeutics

authors： Summers KH

更新日期：1996-11-01 00:00:00

abstract：:A drug surveillance study was performed to determine the tolerance and safety of quinapril in the treatment of patients with stage 1 or 2 hypertension. The trial was noncomparative, open-label, uncontrolled, and nonrandomized. Patients with secondary hypertension, heart failure, other heart diseases, and other serious...

journal_title：Clinical therapeutics

authors： Olvera S,Alcocer L,Novoa G

更新日期：1996-09-01 00:00:00

abstract：:A randomized, double-masked, parallel-group, multicenter clinical trial was conducted to compare the efficacy, tolerability, and effects on quality of life associated with treatment regimens including the angiotensin II receptor antagonist losartan, with hydrochlorothiazide (HCTZ) added as needed, with regimens includ...

journal_title：Clinical therapeutics

authors： Oparil S,Barr E,Elkins M,Liss C,Vrecenak A,Edelman J

更新日期：1996-07-01 00:00:00

abstract：:Congestive heart failure (CHF) afflicts more than 4.6 million people in the United States and increases at a rate of 400,000 newly diagnosed patients per year. With more than 1.5 million hospital admissions per year attributed to CHF, it is the number one cause of hospitalization. Hospital length of stay (LOS) is one ...

journal_title：Clinical therapeutics

authors： Simons WR,Haim M,Rizzo J,Zannad F

更新日期：1996-07-01 00:00:00

abstract：:The efficacy and tolerability of a twice-daily dose of 5 mg of nisoldipine versus 40 mg of sustained-release isosorbide dinitrate (ISDN) were compared in a randomized, double-masked study in 91 patients. During the 21-day treatment period, the mean time taken during bicycle ergometry to the appearance of an ST segment...

journal_title：Clinical therapeutics

authors： Heublein B,Amende I,Blanke PM,Baunack-Frost AR,Breuer HW

更新日期：1996-05-01 00:00:00

abstract：:This prospective, clinical economic study was done to determine the cost impact of oral compared with intravenous (i.v.) ganciclovir for the maintenance treatment of newly diagnosed cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS). Efficacy and safety data were extracted from ...

journal_title：Clinical therapeutics

authors： Sullivan SD,Mozaffari E,Johnson ES,Wolitz R,Follansbee SE

更新日期：1996-05-01 00:00:00

abstract：:The bacteriologic profile in 1081 pediatric patients with culture-positive symptomatic bacteriuria was studied over a 30-month period in a 500-bed acute care hospital in Riyadh, Saudi Arabia. Microbial isolates were considered significant if their numbers equaled or exceeded 10,000 colony-forming units/mL in symptomat...

journal_title：Clinical therapeutics

authors： al-Mugeiren MM,Qadri SM

更新日期：1996-03-01 00:00:00

abstract：:Patient counseling is an important aspect of family planning. Patient choice, compliance, and satisfaction with a contraceptive method depend heavily on the counseling experience. This is especially true in the United Kingdom where contraceptives are provided to patients at no direct cost to them. Women are therefore ...

journal_title：Clinical therapeutics

authors： Davie JE,Walling MR,Mansour DJ,Bromham D,Kishen M,Fowler P

更新日期：1996-01-01 00:00:00

abstract：:The causes of past accidental viral transmissions associated with blood derivatives are reviewed briefly, as are the safety procedures instituted in Europe on the basis of viral validation studies. A comprehensive five-class classification system for delineating viral risk according to source material and comparative ...

journal_title：Clinical therapeutics

authors： Horaud F

更新日期：1996-01-01 00:00:00

abstract：:This article reviews the administration, efficacy, and safety of prophylactic intravenous immunoglobulin in patients with secondary immunodeficiency and those undergoing allogeneic bone marrow transplantation. Associated infections in these immunosuppressed patients are examined as they relate to transfusion-associate...

journal_title：Clinical therapeutics

authors： Sullivan KM

更新日期：1996-01-01 00:00:00

abstract：:This multicenter, randomized, double-blind study compared the efficacy and tolerability of ondansetron 8 mg twice daily for 3 days with placebo in preventing nausea and vomiting in 81 patients receiving cyclophosphamide-doxorubicin-based chemotherapy. The first dose of study drug was administered 30 minutes before the...

journal_title：Clinical therapeutics

authors： DiBenedetto J Jr,Cubeddu LX,Ryan T,Kish JA,Sciortino D,Beall C,Eisenberg PD,Henderson C,Griffin D,Wentz A

更新日期：1995-11-01 00:00:00

abstract：:In trying to identify the therapeutic impact of a drug, clinical trials eliminate potentially confounding factors such as comorbidities, poor compliance and treatment errors in diagnosis, dosing, and drug interactions. Elimination of these variables means that attempts to use clinical data as the basis for predicting ...

journal_title：Clinical therapeutics

authors： Langley PC

更新日期：1995-11-01 00:00:00

abstract：:Exposure of the eye to airborne particles in patients predisposed to allergy often results in the signs and symptoms of allergic conjunctivitis such as red, itchy eyes and ocular discharge. The mediators of these allergic symptoms include histamine, inflammatory substances such as prostaglandins, and other products of...

journal_title：Clinical therapeutics

authors： Raizman MB

更新日期：1995-09-01 00:00:00

abstract：:The Southern California region Kaiser Permanente Medical Care Program, which serves 2.2 million patients, and the University of Southern California School of Pharmacy have designed and implemented a patient consultation study to determine the cost-effectiveness of three different approaches to providing pharmacist con...

journal_title：Clinical therapeutics

authors： Johnson KA,Nye M,Hill-Besinque K,Cody M

更新日期：1995-09-01 00:00:00

abstract：:The effects of long-term treatment with nipradilol, a nitroester-containing beta-blocker, on casual and 24-hour blood pressures were studied in 70 patients with mild-to-moderate essential hypertension. Antihypertensive effects of nipradilol on casual blood pressure were observed in 68% of patients. Nipradilol reduced ...

journal_title：Clinical therapeutics

authors： Haneda T,Ogawa Y,Akaishi T,Takeda H,Tanazawa S,Inoue H,Ohki Y,Kato J,Morimoto H,Kanaya K

更新日期：1995-07-01 00:00:00

abstract：:The US population is multiethnic in composition: many languages thrive, and Spanish is the second most frequently spoken language. The Hispanic population is one of the fastest growing ethnic groups in the United States. The majority of Hispanics speak Spanish at home (63%), and a significant proportion speak little o...

journal_title：Clinical therapeutics

authors： Arocho R,Kason NM,Colón B,McMillan CA

更新日期：1995-07-01 00:00:00

abstract：:A prospective, open-label, multicenter, Phase IV study of the efficacy and safety of intravenous (IV) ciprofloxacin (400 mg by 60-minute infusion every 12 hours) in the treatment of lower respiratory tract infections (LRTIs), urinary tract infections (UTIs), and skin/skin structure infections (SSSIs) in hospitalized p...

journal_title：Clinical therapeutics

authors： Pankey GA

更新日期：1995-05-01 00:00:00

abstract：:The effects of treatment with epalrestat, an aldose reductase inhibitor, on peripheral neuropathy were studied in 45 patients with non-insulin-dependent diabetes mellitus (NIDDM). Epalrestat 150 mg three times daily was given for 24 weeks. Subjective symptoms, such as spontaneous pain in the lower extremities and numb...

journal_title：Clinical therapeutics

authors： Uchida K,Kigoshi T,Nakano S,Ishii T,Kitazawa M,Morimoto S

更新日期：1995-05-01 00:00:00

abstract：:The cost of induction and maintenance of anesthesia is analyzed in this article from the perspective of a health maintenance organization's (HMO) chief financial officer. While earlier economic studies tended to focus on the raw cost of anesthesia drugs, our model also includes the cost of the clinical labor involved ...

journal_title：Clinical therapeutics

authors： Suver J,Arikian SR,Doyle JJ,Sweeney SW,Hagan M

更新日期：1995-05-01 00:00:00

abstract：:The objective of this study was to compare the lipid-altering efficacy and safety of simvastatin with that of gemfibrozil in hypercholesterolemic patients with non-insulin-dependent diabetes mellitus (NIDDM). The study was a 24-week, double-blind, randomized, multicenter trial conducted at clinics and hospitals in the...

journal_title：Clinical therapeutics

authors： Sweany AE,Shapiro DR,Tate AC,Goldberg RB,Stein EA

更新日期：1995-03-01 00:00:00

abstract：:A parallel-group, randomized, double-blind, forced-titration, multicenter study was done to compare the efficacy and safety of once-daily nifedipine coat-core (NIF CC) and once-daily nifedipine gastrointestinal therapeutic system (NIF GITS) dosed in the fasting state in patients with mild-to-moderate essential hyperte...

journal_title：Clinical therapeutics

authors： Glasser SP,Ripa SR,Allenby KS,Schwartz LA,Commins BM,Jungerwirth S

更新日期：1995-03-01 00:00:00

abstract：:The antiemetic efficacy and tolerability of four different oral doses of granisetron (0.25, 0.5, 1, and 2 mg twice daily [BID]) were compared in a randomized, double-blind, parallel-group, multicenter study involving 930 patients with malignant disease receiving moderately emetogenic chemotherapy over a 7- or 14-day p...

journal_title：Clinical therapeutics

authors： Bleiberg HH,Spielmann M,Falkson G,Romain D

更新日期：1995-01-01 00:00:00

abstract：:We investigated the usefulness of the C64 quantitative tuning fork in assessing vibratory sensation in patients with diabetic neuropathy. The vibratory sensation scores determined by using the C64 quantitative tuning fork were significantly correlated with severity of subjective symptoms of numbness, cold, desensitiza...

journal_title：Clinical therapeutics

authors： Hotta N,Sugimura K,Tsuchida I,Sano T,Koh N,Matsumae H,Sakamoto N

更新日期：1994-11-01 00:00:00

abstract：:This study evaluated the efficacy, safety, and most suitable dose of omeprazole in short-term acute treatment (4 weeks) and maintenance treatment (6 months) of patients older than 60 years of age with endoscopically diagnosed gastric ulcer (GU) or duodenal ulcer (DU). This randomized, prospective study included 156 pa...

journal_title：Clinical therapeutics

authors： Pilotto A,Di Mario F,Battaglia G,Vigneri S,Leandro G,Franceschi M,De Boni M,Grasso A,Vianello F,Naccarato R

更新日期：1994-11-01 00:00:00

abstract：:Twenty-five patients with typhoid fever, who were resistant to amoxicillin and chloramphenicol, were successfully treated with ofloxacin. Ofloxacin was administered at a dosage of 200 mg three times daily for 7 to 10 days. In a few seriously ill patients, a dosage of 400 mg three times daily for 3 days, followed by 20...

journal_title：Clinical therapeutics

authors： Khan MA,Hayat Z,Sadick A

更新日期：1994-09-01 00:00:00

abstract：:This article reviews the drugs used in the treatment of childhood asthma (bronchodilators and anti-inflammatory agents) from the perspective of their safety and clinical tolerability. Adverse events observed in adults are likely to be seen to a greater degree in children and adolescents for many types of antiasthma dr...

journal_title：Clinical therapeutics

authors： Selcow JE

更新日期：1994-07-01 00:00:00

abstract：:Recent pharmacotherapeutic advances in the treatment of depression have included the development of selective serotonin re-uptake inhibitors (SSRIs). The present study was designed to contrast direct health service expenditures for the treatment of depression among patients enrolled in a health maintenance organizatio...

journal_title：Clinical therapeutics

authors： Sclar DA,Robison LM,Skaer TL,Legg RF,Nemec NL,Galin RS,Hughes TE,Buesching DP

更新日期：1994-07-01 00:00:00

abstract：:In an open, multicenter trial, 329 patients (who attended gastroenterology practices or outpatient gastroenterology departments of hospitals) with a mean age of 47.3 years, received 5 mg of cisapride three times a day (TID) for at least 2 weeks for the treatment of persistent, recurring symptoms of functional dyspepsi...

journal_title：Clinical therapeutics

authors： Rösch W

更新日期：1994-05-01 00:00:00

abstract：:This paper reviews the issues that are critical for the valuation of medical resources in the context of health economic studies. There are several points to consider when undertaking the valuation of medical resources. The perspective of the analysis should be established before determining the valuation process. Fut...

journal_title：Clinical therapeutics

authors： Copley-Merriman C,Lair TJ

更新日期：1994-05-01 00:00:00

abstract：:As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates. Nitrates are converted to nitric oxide, resulting in vasodilator effects t...

journal_title：Clinical therapeutics

authors： Frishman WH,Amsterdam E,Glasser SP,Thadani U

更新日期：1994-03-01 00:00:00

abstract：:Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid family with demonstrated efficacy in the treatment of rheumatoid arthritis and osteoarthritis; a distinguished safety profile; and good tolerability. This report describes a new extended-release formulation that maintains therapeutic pla...

journal_title：Clinical therapeutics

authors： Schumacher HR Jr

更新日期：1994-03-01 00:00:00

abstract：:A 1-year, open-label extension of a 12-week, double-blind clinical trial was conducted to evaluate the long-term safety and efficacy of once-daily therapy with triamcinolone acetonide nasal aerosol (110, 220, or 440 micrograms) in 93 patients with perennial allergic rhinitis. All three doses of triamcinolone acetonide...

journal_title：Clinical therapeutics

authors： Welch MJ,Bronsky E,Findlay S,Pearlman DS,Southern DL,Storms WW,Weakley S

更新日期：1994-03-01 00:00:00